TBTU (O-(Benzotriazol-1-yl)-N,N,N’,N’-Tetramethyluronium Tetrafluoroborate)
TBTU is a coupling reagent used for solid-phase peptide synthesis. The compound has been used to study ten different phosphonium and uronium salt-based coupling reagents, which are used to synthesize four peptides. TBTU has been documented as a coupling reagent to synthesize a tetrahydrocarbazole substituted dipeptide in a multi-gram solid-phase synthesis. The compound has also been incorporated with HOBt (hydroxybenzotriazole dihydrate) as a carboxyl activator before the coupling of a C-terminal amino acid with a success rate of 100% coupling.
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Peptide Reagents, Resins & Linkers
|Formula||C11H16N5O · BF4|
|Storage Conditions||Room temperature|
|MSDS Data Sheet||Click to download|
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