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Pepstatin A

Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.

Often used with Leupeptin and PMSF to make up in house preparations of protein inhibitor cocktails.

Pepstatin can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. For this application, the working concentration is typically between 1-10 μM.

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Product Details

Category Biochemicals & Diagnostics
Price Custom packed. Request price on line.
CAS Number 26305-03-3
Formula C34H63N5O9
Molecular Weight 685.89
Purity 90.0%
Appearance solid form
Availability In Stock
Storage Conditions +4°C
MDL Number Request if not shown

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