Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin.
Often used with Pepstatin and PMSF to make up in house preparations of protein inhibitor cocktails.
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Biochemicals & Diagnostics
|Price||Custom packed. Request price on line.|
|Formula||C20H38N6O4 · 1/2H2SO4|
|MDL Number||Request if not shown|
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