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Potent and selective non-competitive mGluR5 antagonist that displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50=87nM). Acts at an allosteric modulatory site shared with MPEP (Prod. No. ALX-550-368) and binds mGluR5 with Kd values of 54nM and 31nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo.

Product Details

Category API's & Drug Standards
Price POA
CAS Number 57653-26-6
Formula C11H11ClN4O2
Molecular Weight 266.68
Purity 98.0%
Appearance Off-white to pale orange solid.
Availability In Stock
Storage Conditions +4°C

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