It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar ‘handle’ which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis.
Heterocycles & Building Blocks
|Formula||C6H6ClN · HCl|
|Appearance||cream or pale yellow or pale brown powder|
|Storage Conditions||Room temperature|
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