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Sumatriptan (succinate) is a serotonin 5-hydroxytryptamine 1 (5-HT₁) receptor agonist with selective affinity for 5-HT_1B and 5-HT_1D receptors with IC₅₀values of 9.3 and 7.3 nM, respectively. It also has affinity for the 5-HT_1F receptor .¹ Sumatriptan has been shown to induce vasoconstriction of human middle meningeal arteries and reduce vascular inflammation associated with migraines.

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