Spergualin is an antibiotic isolated from Bacillus laterosporus that has antibacterial, antitumor, and strong immunosuppressive properties. Spergualin exhibits antitumor activity against transplantable leukemias in mice such as lymphatic leukemia L1210, monocytic leukemia P388, mastocytoma P815, or thymoma EL-4. Spergualin was found effective in inhibiting skin graft rejection, preventing GVHD (Graft-Versus-Host-Disease) in mice recipients of allogeneic bone marrow and spleen cells, and modulating other immunologic diseases.
Antibiotics & Antibacterials
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