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Nigericin Sodium Salt

Nigericin sodium salt, a polyether antibiotic K+ and Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential and stimulates ATPase activity leading to rapid intracellular acidification resulting in apoptosis. Nigericin•Na has shown a role for inducing caspase-1-independent necrotic cell death. Nigericin•Na has also been found to increase membrane potential accelerating the rate of superoxide generation approaching the rate obtained by antimycin. Nigericin•Na is an activator of Cryopyrin.

Product Details

Category Antibiotics & Antibacterials
Price POA
CAS Number 28380-24-7
Formula C40H67NaO11
Molecular Weight 746.94
Purity 98.0%
Appearance white to off-white powder
Availability In Stock
Storage Conditions +4°C

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