Latrunculin A, Latrunculia Magnifica
Latruculin A is a macrolide toxin isolated from the red sea sponge Latrunculia magnifica. Latruculin A binds and stabilizes globular G-actin in a 1:1 complex, preventing the conversion of globular (monomeric) G-actin into filamentous (polymeric) F-actin, disturbing microfilament organization in the cell. The equlibrilium dissociaion constant for the reaction in cultured cell is 0.1-1 μM. Polymerization of G-actin and microfilament organization is essential for cellular mechanical processes including motility and cytoskeleton scaffolding, and disruption of this by Latruculin A affects normal functioning of the cell. Latrunculin A, Latrunculia magnifica is an inhibitor of Actin.
Antibiotics & Antibacterials
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