Dasatinib Monohydrate
Dasatinib is a 2-aminothiazole-derived inhibitor of Src family kinases. Dasatinib inhibits c-Abl and Bcr-Abl tyrosine kinase activity and shows efficacy against imatinib-resistant Bcr-Abl mutations.Dasatinib is an anticancer chemotherapeutic compound that inhibits Abl, PDGFR, ephrin receptors, Src, c-Kit, and other Src-family kinases (LCK, HCK, FYN, and others). Dasatinib is clinically used to treat chronic myelogenous leukemia (CML) and acute lymphocytic leukemia; in acute myelogenous leukemia (AML) cells, dasatinib induces myeloid differentiation and autophagy. Dasatinib also displays antiviral activity, preventing dengue virus infection through its inhibition of FYN kinase.
Product Details
| Category |
Cancer Research and Antivirals |
|---|---|
| Price | POA |
| CAS Number | 863127-77-9 |
| Formula | C22H28ClN7O3S |
| Molecular Weight | 506.02 |
| Purity | 98.0% |
| Appearance | powder solid |
| Availability | In Stock |
| Storage Conditions | -18°C |
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