Colistin Sodium Methanesulfonate
Colistin sodium methanesulfonate (also known as Colistin Methosulfate) is a cyclopolypeptide antibiotic with endotoxin-binding capacity Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect. It is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients.
It is often used for treatment of infections caused by gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae where other therapeutic options are ineffective.
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