Antibiotic LL Z1640-2
Antibiotic LL Z1640-2 is a signal-specific inhibitor of the JNK/p38 pathways that has been shown to inhibit anisomycin-induced but not TNF-induced JNK/p38 activation. Shown to inhibit HgCl2 and CdCl2 MAPKs activation, while not affecting total protein level, in CCRF-CEM and NIH3T3 cells, respectively. Like other members of the resorcylic acid lactone (RAL) family, LL-Z1640-2 targets the ATP-binding pocket of kinases. Unlike other RALs, irreversibly inhibits TAK1. This cis-enone resorcylic acid lactone was first reported in 1978 and later rediscovered as an irreversible and highly selective TAK1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines.
Product Details
| Category |
Antibiotics & Antibacterials |
|---|---|
| Price | POA |
| CAS Number | 66018-38-0 |
| Formula | C19H22O7 |
| Molecular Weight | 362.37 |
| Purity | 99.0% |
| Appearance | solid form |
| Availability | In Stock |
| Storage Conditions | -18°C |
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