You can email us at info@discofinechem.com, or call us on 01202 539791.Email: info@discofinechem.com. Phone: 01202 539791.

Products

Antibiotic LL Z1640-2

Antibiotic LL Z1640-2 is a signal-specific inhibitor of the JNK/p38 pathways that has been shown to inhibit anisomycin-induced but not TNF-induced JNK/p38 activation. Shown to inhibit HgCl2 and CdCl2 MAPKs activation, while not affecting total protein level, in CCRF-CEM and NIH3T3 cells, respectively. Like other members of the resorcylic acid lactone (RAL) family, LL-Z1640-2 targets the ATP-binding pocket of kinases. Unlike other RALs, irreversibly inhibits TAK1. This cis-enone resorcylic acid lactone was first reported in 1978 and later rediscovered as an irreversible and highly selective TAK1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines.

Product Details

Category Antibiotics & Antibacterials
Price POA
CAS Number 66018-38-0
Formula C19H22O7
Molecular Weight 362.37
Purity 99.0%
Appearance solid form
Availability In Stock
Storage Conditions -18°C

Product Enquiry

Send us your enquiry for Antibiotic LL Z1640-2. We offer custom pack sizes at special prices. We aim to respond to your enquiry within 24 hours.

We value your input so if you have suggestions regarding new applications for Antibiotic LL Z1640-2 email us and we will include your contribution on the website.

Enquire about product

Discovery Newsletter

ISO 9001: Certificate FS 648315

nach oben