5-Aminolevulinic Acid Hydrochloride
5-Aminolevulinic acid Hydrochloride is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll in plants.
In plants, production of δ-ALA is the step on which the speed of synthesis of chlorophyll is regulated. Plants that are fed by external δ-ALA accumulate toxic amounts of chlorophyll precursor, protochlorophyllide, indicating that the synthesis of this intermediate is not suppressed anywhere downwards in the chain of reaction. Protochlorophyllide is a strong photosensitizer in plants.
In Cosmetics,Aminolevulinic acid (ALA) has demonstrated highest efficacy in topical PDT, and has become the most clinically useful. For actinic (solar) keratoses, topical ALA-PDT using Levulan® Kerastick™ (20% topical solution, DUSA Pharmaceuticals) is already postulated to be the treatment of choice. In December 1999, the US FDA approved this topical product for the treatment of actinic keratoses.
Biochemicals & Diagnostics
Cancer Research and Antivirals
Cosmetic Raw Materials
|Formula||C5H9NO3 · HCl|
|Storage Conditions||-18 °C|
|MSDS Data Sheet||Click to download|
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