4-MU (4-Methylumbelliferone)
4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling.
Product Details
| Category |
Biochemicals & Diagnostics |
|---|---|
| Price | POA |
| CAS Number | 90-33-5 |
| Formula | C21H27N7O14P2 · xH2O |
| Molecular Weight | 176.17 |
| Purity | 99.0% |
| Appearance | off white to yellow powder |
| Availability | In Stock |
| Storage Conditions | -18℃ |
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