Tetrazoles are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen and one carbon atom (plus hydrogens). The simplest is tetrazole itself, CH2N4. They are unknown in nature.There are several pharmaceutical agents which are tetrazoles. The tetrazole ring can act as a bioisostere for the carboxylate group. Angiotensin II receptor blockers – such as losartan and candesartan, often are tetrazoles. A well-known tetrazole is dimethyl thiazolyl diphenyl tetrazolium bromide (MTT). This tetrazole is used in the MTT assay to quantify the respiratory activity of live cells culture, although it generally kills the cells in the process. Some tetrazoles can also be used in DNA assays.
Peptide Reagents, Resins & Linkers
|Appearance||white to light yellow crystalline powder|
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