(S)-10-Hydroxycamptothecin
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. (S)-10-Hydroxycamptothecin is an inhibitor of Topo I.(S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM).2 In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.3
Product Details
| Category |
Cancer Research and Antivirals |
|---|---|
| Price | POA |
| CAS Number | 19685-09-7 |
| Formula | C20H16N2O5 |
| Molecular Weight | 364.35 |
| Purity | 98.0% |
| Appearance | solid form |
| Availability | In Stock |
| Storage Conditions | -18°C |
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