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Pranlukast brand name Onon, is a cysteinyl leukotriene receptor-1 antagonist. The cysteinyl leukotrienes (CysLT) LTC₄ and LTD₄ are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT₁ and CysLT₂. Pranlukast (ONO-1078) is a potent, selective and orally active cysteinyl leukotriene1 (CysLT₁) receptor antagonist. Sold under the trade name Ultair, it was the first cysteinyl (peptidyl) leukotriene receptor antagonist (LTRA) marketed for the treatment of asthma.

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