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Tacrolimus (FK-506)

FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation.

Product Details

Category Pharma Compounds & Neutraceuticals
Price Custom packed. Request price on line.
CAS Number 104987-11-3
MDL Number Request if not shown
Formula C53H79NO14D4
Molecular Weight 962.25
Appearance crystalline solid
Purity 99.0%
Storage Conditions -18°C

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