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Glibenclamide (Glyburide)

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Clchannel blocker. This compound inhibits recombinant CFTR Cl channels (IC50 = 20 μM).

Product Details

Category API's & Drug Standards
Price POA
CAS Number 10238-21-8
Formula C23H28ClN3O5S
Molecular Weight 494.00
Appearance white to off white powder
Purity 98.0%
Storage Conditions +4°C

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