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DL-Amethopterin Hydrate

Amethopterin is a folic acid antagonist and potent anticancer agent. Amethopterin blocks DNA synthesis by preventing the production of tetrahydrofolate cofactors which are required to make thymidine. Amethopterin is actively transported into cells by the folate transporter where it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, a dihydrofolate reductase inhibitor.

Product Details

Category API's & Drug Standards
Cancer Research and Antivirals
Price POA
CAS Number 60388-53-6
Formula C20H22N8O5
Molecular Weight 454.44
Appearance yellow to orange crystalline powder
Purity 96.0%
Storage Conditions -18°C

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