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Antibiotic LL Z1640-2

Antibiotic LL Z1640-2 is a signal-specific inhibitor of the JNK/p38 pathways that has been shown to inhibit anisomycin-induced but not TNF-induced JNK/p38 activation. Shown to inhibit HgCl2 and CdCl2 MAPKs activation, while not affecting total protein level, in CCRF-CEM and NIH3T3 cells, respectively. Like other members of the resorcylic acid lactone (RAL) family, LL-Z1640-2 targets the ATP-binding pocket of kinases. Unlike other RALs, irreversibly inhibits TAK1. This cis-enone resorcylic acid lactone was first reported in 1978 and later rediscovered as an irreversible and highly selective TAK1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines.

Product Details

Category Antibiotics & Antibacterials
Price POA
CAS Number 66018-38-0
Formula C19H22O7
Molecular Weight 362.37
Appearance solid form
Purity 99.0%
Storage Conditions -18°C

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